NLRP3inflammasome相关论文
Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexinl in acute kidney dise
Ischemia/reperfusion(I/R)injury is a major cause of acute kidney injury(AKI)in clinic.The activation of NLRP3 inflammaso......
目的:研究高糖通过激活NLRP3炎症小体对胎盘滋养细胞白细胞介素(IL)-1β和IL-18分泌的影响。方法:收集妊娠期糖尿病(GDM)胎盘和对......
NLRP3 inflammasome activation determines the fibrogenic potential of PM2.5 air pollution particles i
Airborne fine particulate matter (PM2.5) is known to cause respiratory inflammation such as chronic obstructive pulmonar......
脓毒症（sepsis）是目前最普遍的感染性疾病之一，炎性反应是脓毒症由轻度转化为脓毒症休克的重要机制。NOD样受体蛋白3（NOD-like recepto......
1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experiment
NOD-like receptor (NLR) family pyrin domain-containing-3 (NLRP3) inflammasome is implicated in inflammation-associated d......
Lp-PLA2 inhibition prevents Ang Ⅱ-induced cardiac inflammation and fibrosis by blocking macrophage N
Macrophage-mediated inflammation plays an important role in hypertensive cardiac remodeling,whereas effective pharmacolo......
NLRP3 inflammasome signal pathway involves in Vibrio harveyi-induced inflammatory response in murine
Vibrio harveyi,an important zoonotic pathogen,can infect wounds and cause inflammatory response.Understanding the inflam......
目的:1.探究S1P及其受体在狼疮肾炎中的表达情况2.探究S1P/S1PR1信号通路在狼疮肾炎中发挥的作用3.探究S1P/S1PR1信号通路在调控肾......
Effect of lipoxin receptor agonist BML-111 on the NLRP3 inflammasome after traumatic brain injury in
Objective: To investigate the effect of lipoxin receptor agonist BML-111 on the NLRP3 inflammasome after traumatic brain......
Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inac
Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates with the occurrence and progression......
Protective mechanisms of Agrimonia pilosa Ledeb in dextran sodium sulfate-induced colitis as determi
Previous studies reported that Agrimonia pilosa (AP) Ledeb possessed diverse biological activi-ties,including anti-infla......
NLRP3是位于细胞质中的模式识别受体,属于NOD样受体家族.在多种危险相关分子模式和病原体相关分子模式的激活下,NLRP3受体通过招募......
With the extensive development and application of rare earth element(REEs),the content of REEs in some foods exceeds the......
Advanced Glycation End Products promote human intervertebral disc degeneration via NLRP3inflammasome
Objective:Intervertebral disc(IVD)degeneration is widely recognized as a contributor to low back pain,neurological dysfu......
The immunotherapeutic effects of Astragalus polysaccharide in dextran sulfate sodium-induced colitis
Aim: Astragalus polysaccharide (APS) is an important bioactive component of Astragalus membranaceus (AM), an herb used i......
EA alleviates depressive-like behaviors and pathological changes in hippocampus in chronic unpredict
...
BACKGROUND&Aims: The NLRP3 inflammasome is a cytosolic multi-protein complex and assembled in response to both DAMP and ......
Hydrogen Sulfide attenuates intracerebral hemorrhage-Induced NLRP3 inflammasome activation and brain
Innate immune and inflammatory responses are important factors in the pathophysiology of secondary brain injury followin......
Objective: The incidence of colorectal cancer ranked the third in men and the second in women.High aggressiveness of col......
Pseudomonas aeruginosa activates NLRP3 inflammasome to evade intracellular killing by triggering aut
Recently, assembly of inflammasome has been identified as a critical event to initiate inflammation.However, its role in......
Activating cannabinoid receptor 2 alleviates pathogenesis of experimental autoimmune encephalomyelit
Aim Activation of cannabinoid receptor 2 (CB2R) has been reported to ameliorate the pathogenesis of experimental autoimm......
Background Previous researches have shown RNAⅢ-inhibiting peptide (RIP) could effectively inhibit the quorum sensing (Q......
Evidences from both clinical and experimental researches indicate that the immune-depression interactions play pivotal r......
NLRP3 inflammasome activation involved in the acute exacerbation and pulmonary function decline in c
目的 NLR pyrin domain-containing protein 3 (NLRP3)inflammasome, a multi-protein complex that activates the caspase-1 cas......
TIFA(TRAF-interacting protein with forkhead-associated domain)is a small FHA-containing human protein.It was first ident......
IgA nephropathy (IgAN) is the most common cause of primary glomerular disorders.Inflammatory responses have been shown t......
Purpose Amyloid β(Aβ)peptide,a major component of drusen which is the hallmark of age-related macular degeneration(AMD......
Activated microglia promote oxygen-glucose deprivation/reperfusion induced retinal ganglion cells ap
Purpose Retinal ischemia/reperfusion(I/R)injury causes the death of retinal ganglion cells(RGCs),however the underlying ......
Background: With the changes of peoples living and eating habits, the incidence of colorectal cancer ranked the third in......
EA alleviates depressive-like behaviors and pathological changes in hippocampus in chronic unpredict
Depression is a leading cause of mortality and morbidity worldwide and results from a combination of genetic and environ......
Icariin,a flavonoid extracted from the traditional Chinese herb Herba Epimedii that can cross the blood-brain barrier fr......
The NLRP3 inflammasome activated by reactive oxygen species in 5-fluorouracil-chemoresistance of ora
Objective:5-fluorouracil (5-FU) is a standard chemotherapeutic agent for local and distant metastatic oral squamous cell......
Lipidmocis Reveals the Mechanism that Hyperhomocysteinemia-induced inflammation and Insulin Resistan
Type 2 diabetes is a chronic inflammatory metabolic disease,the key point being insulin resistance.NLRP3 inflammasome pl......
OBJECTIVE Interleukin (IL)-1β, one of the principal inflammatory cytokines mainly secreted by mono?cytes and macrophage......
Tanshinone ⅡA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehy
Metabolic reprogramming is associated with NLRP3 inflammasome activation in activated macrophages,contributing to inflam......
TAX1BP1 protects against myocardial infarction-associated cardiac anomalies through inhibition of in
Acute myocardial infarction(MI),one of the most common cardiovascular emergencies,is a leading cause of morbidity and mo......
Background:Innate immune system plays an important role in opposing pathogen invasion through certain mechanisms such as......
The essential oils from Rimulus cinnamon(EORC)has antiinflammation activities,but the EORC on endotoxin poisoning mi......
The aim of this study was to identify the effects of melatonin on acute gouty inflammation and to investigate the underl......
目的以佛波酯(PMA)诱导分化的THP-1巨噬细胞为模型,探讨NLRP3炎性小体在幽门螺杆菌Tipα蛋白诱导炎性细胞因子分泌中的作用。方法......
动脉粥样硬化是心脑血管疾病发生的共同病理基础，动脉粥样硬化的形成与炎症反应关系密切。最近研究表明，天然免疫应答和获得性免疫应......
核苷酸结合寡聚化结构域样受体蛋白3炎症小体作为固有免疫的重要组成部分,在高血压的发生发展中起着重要的作用.核苷酸结合寡聚化......
血栓闭塞性脉管炎(TAO)是中、小动静脉的一种节段性、闭塞性的慢性炎性疾病,其特点为病变血管的血栓形成和血管闭塞.TAO是一种影响......
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Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF
Inflammation plays important roles in the progress of neurodegenerative diseases,such as Parkinson's disease and Alzheim......
Liver ischemia/reperfusion injury(IRI),a serious inflammatory response driven by innate immu-nity,occurs in liver surger......
Background:Inflammation is an essential component of liver diseases.Paeoniflorin(PF),a monoterpenoid component derived f......
